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Nonopioid Analgesic Drugs

NONOPIOID ANALGESIC DRUGS

-Classification

  1. Para-aminiphenols
    • Paracetemol
  2. Pyrazolones
    • Metamizole

PARACETEMOL

  • Pharmacokinetic:  Its given orally and is metabolized in the liver by conjugation with glucuronic acid  and sulfate and by oxidation (half-life 2/4 hours)
  • Effects : Analgesic and Antipyretic
  • Mechanism of action : Selective inhibition of COX-3 –the reason for the difference from the other NSAIDs (lack of clinically significant anti-inflammatory effect)
  • The analgesic and antipyretic drug of choice in childeren and in pregnancy.

 

PARACETEMOL ADVERSE EFFECTS AND POISONING

  • Analgesic assosiated with nephropaty following prolonged use
    • With toxic doses paracetamol causes serious liver damage.
    • Renal toxicity may also follow.

METAMIZOLE

  • Analgesia-different kinds of pain , including visceral
  • Antipyretic

 

ADVERSE EFFECTS

  • Bone marrow suppression(aplastic anemia)
  • Allergic reactions
  • Analgesic-assosiated nephropathy following prolonged use.

 

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About The Author
Kadir Timuçin Güneren
Kadir Timuçin Güneren
F*** the medicine!
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